Important Product Information
TOPROL-XL (metoprolol succinate) extended-release
tablets is used to treat high blood pressure, angina pectoris over the long
term, and heart failure. In heart failure, TOPROL-XL is used to treat stable,
symptomatic patients with Class II or III heart failure, as defined by the New
York Heart Association classification, that is caused by high blood pressure,
blocked heart arteries, or other heart muscle disorders. It was studied in
patients who were already taking other medications for heart failure.
TOPROL-XL should not be taken by people with the following
-
Extreme slowing of the heart rate (known as severe bradycardia)
-
A sudden and severe drop in the blood pressure and blood flow through the body
because the heart is not pumping normally (also known as cardiogenic shock)
-
Uncontrolled heart failure (known as decompensated heart failure)
-
A slowdown of the heart's electrical signal (also known as heart block) as it
travels through the heart causing a slower heart rate. There are different
types or degrees of slowdown. TOPROL-XL should not be taken by patients who
have second-degree or third-degree (complete) heart block
-
Damage to the heart's natural pacemaker that causes the heart to beat too fast
or too slow [unless a pacemaker device is in the body] (also known as sick
sinus syndrome)
-
An allergy to TOPROL-XL or any of its ingredients
Be sure to discuss any questions with your doctor. Your doctor will decide the
best course of treatment for you after assessing your particular medical
condition.
It is important to take your medications as directed by your doctor.
Patients should not stop taking TOPROL-XL suddenly because of the possibility of
serious side effects, such as chest pain or a heart attack. If your doctor
decides you should stop taking TOPROL-XL, your doctor may instruct you to
slowly reduce your dose over a period of time before stopping it completely.
In some patients, TOPROL-XL should be used with caution: those with asthma or
asthma-like lung disease or those who are taking certain calcium channel
blockers, have diabetes, overactive thyroid disease, hardening or constriction
of the arteries in the arms or legs, or are planning to have surgery.
Talk to your doctor about your health history, and be sure to tell your doctor
if you are taking TOPROL-XL or any other medications.
Until you know how you will react to TOPROL-XL, avoid activities that require
alertness.
In clinical trials of patients with high blood pressure and angina pectoris, the
most commonly reported side effects with immediate release metoprolol tartrate
are: tiredness (10%), dizziness (10%), depression (5%), diarrhea (5%), itching
or rash (5%), shortness of breath (3%), and slow heart rate (3%). If you
experience any of these or other side effects, contact your doctor.
In a large heart failure clinical study, serious side effects and side effects
leading to discontinuation of TOPROL-XL included dizziness/vertigo, slow heart
rate, and accident and/or injury. These side effects occurred in 1% to 2% of
the patients in the study. If you experience any of these or other side
effects, contact your doctor.
The information on this site cannot replace the advice of your doctor.
Detailed information about TOPROL-XL, including full
Prescribing Information and boxed WARNING regarding suddenly stopping
the use of TOPROL-XL, is available to you and to your doctor.
Please discuss the Prescribing Information and any specific questions about
your own or a loved one's medical condition with your or your loved one's
doctor. Only he or she can recommend the treatment that is best for you or your
loved one.